Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates
نویسندگان
چکیده
منابع مشابه
Anti-Nociceptive and Anti-Inflammatory Activity of Araucaria bidwillii Hook
The effect of alcoholic extracts of leaf from Araucaria bidwillii Hook. [ABH] (Family: Araucariaceae) was evaluated in experimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg of leaf extracts of ABH were used for the above study. The leaf extract at 300 and 200 mg/kg showed significant reduction in acetic acid induced writhings in mice with a maximum effect o...
متن کاملEvaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives
Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...
متن کاملEvaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives
Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...
متن کاملeffects of aspirin as an anti-inflammatory drug on azole-resistant candida glabrata in vitro
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متن کاملSynthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents.
Eight novel 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized in order to obtain new compounds with potential anti-nociceptive and anti-inflammatory activity. The titled compounds were synthesized by the condensation of 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzotriazole (2) and appropriate acid chlorides. Compound 2 was synthesized by reacting 3-(1H-benzo[d][1,...
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ژورنال
عنوان ژورنال: Acta Poloniae Pharmaceutica - Drug Research
سال: 2020
ISSN: 0001-6837
DOI: 10.32383/appdr/118364